Nk6, a novel Drosophila homeobox gene regulated by vnd
نویسندگان
چکیده
منابع مشابه
Nk6, a novel Drosophila homeobox gene regulated by vnd
Nk(x)-type homeobox genes are an evolutionarily conserved family that regulate diverse developmental processes. Here we describe a novel Drosophila gene, Nk6, which encodes an Nk-type transcription factor most homologous to vertebrate Nkx6.1 and Nkx6.2. The homeodomains and NK decapeptide domains of all three proteins are highly conserved. Nk6 is expressed in the embryonic brain, ventral nerve ...
متن کاملCorrigendum to “Nk6, a novel Drosophila homeobox gene regulated by vnd” [Mech. Dev. 116 (2002) 105–116]
Corrigendum to “Nk6, a novel Drosophila homeobox gene regulated by vnd” [Mech. Dev. 116 (2002) 105–116] Jay Uhler, James Garbern, Li Yang, John Kamholz, Dervla M. Mellerick* Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA Center for Molecular Medicine and Genetics, Wayne State Un...
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The Drosophila CNS develops from three columns of neuroectodermal cells along the dorsoventral (DV) axis: ventral, intermediate, and dorsal. In this and the accompanying paper, we investigate the role of two homeobox genes, vnd and ind, in establishing ventral and intermediate cell fates within the Drosophila CNS. During early neurogenesis, Vnd protein is restricted to ventral column neuroectod...
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In central nervous system development, the identity of neural stem cells (neuroblasts) critically depends on the precise spatial patterning of the neuroectoderm in the dorsoventral (DV) axis. Here, we uncover a novel gene regulatory network underlying DV patterning in the Drosophila brain, and show that the cephalic gap gene empty spiracles (ems) and the Nk6 homeobox gene (Nkx6) encode key regu...
متن کاملNeuroblast pattern formation: regulatory DNA that confers the vnd/NK-2 homeobox gene pattern on a reporter gene in transgenic lines of Drosophila.
DNA fragments -0.57, -2.2, -2.9, -5.3, and -8.4 kb in length from the upstream regulatory region of the vnd/NK-2 gene were cloned in the 5'-flanking region of a beta-galactosidase (beta-gal) reporter gene in the P-element pCaSpeR-AUG-beta-gal, and the effects of the DNA on the pattern and time of expression of beta-gal were determined in transgenic embryos. Embryos from 11 lines transformed wit...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2002
ISSN: 0925-4773
DOI: 10.1016/s0925-4773(02)00155-7